Select Research Articles by Year

2021

2020

2019

2018

Select Review Articles by Year

Research Articles

2021

Macrophage-targeted singled walled carbon nanotubes stimulate phagocytosis via pH-dependent drug release. Nano Research. Y. Zhang, J. Ye, N. Hosseini-Nassab, A. Flores, I. Kalashnikova, S.L. Paluri, M. Lotfi, N.J. Leeper, B.R. Smith* (2021).14, 762-769.

2020

18-FDG-PET imaging detects plaque vulnerability and response to therapeutic intervention in a murine model of advanced atherosclerotic disease. Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB). K. Uwe-Jarr, J. Ye, Y. Kojima, V. Nanda, A.M. Flores, P. Tsantilas, Y. Wang, N. Hosseini-Nassab, A.V. Eberhard, M. Lotfi, M. Kaller, B.R. Smith, L. Maegdefessel, N.J. Leeper (2020). 40(12) 2821-2828.

Reduction Triggered In Situ Polymerization in Living Mice. Journal of the American Chemical Society (JACS). L. Cui, S. Vivona, B.R. Smith, S. Kothapalli, J. Liu, X. Ma, Z. Chen, M. Taylor, P.H. Kierstead, J.M.J. Frechet, S.S. Gambhir, J. Rao (2020). 142(36) 15575-15584.

Particle tracking microrheology of cancer cells in living subjects. Materials Today. P-H, Wu^, S.S. Gambhir^, C. Hale, W-C Chen, D. Wirtz^, B.R. Smith^ (2020). Particle tracking microrheology of cancer cells in living subjects. Materials Today. 39, 98-109. ^Corresponding author. HIGHLIGHTED IN: Science Daily | Phys.org

Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis. Nature Nanotechnology. A. Flores, N. Hosseini-Nassab, K-U, Jarr, J. Ye, X. Zhu, R. Wirka, A.L. Koh, P. Tsantilas, Y. Wang, V. Nanda, Y. Kojima, Y. Zeng, M. Lotfi, R. Sinclair, I.L. Weissman, E. Ingelsson, B.R. Smith*, N. Leeper* (2020). 15(2) 154-161. *Equal and Co-Corresponding authors. [Cover article] HIGHLIGHTED IN: Detroit News | Google News | Paul W. Smith Detroit Radio Show

Nanoparticles decorated with granulocyte-colony stimulating factor for targeting myeloid cells. Nanoscale. K. Margulis, A. Honkala, I. Kalashnikova, S.E. Noll, M. Hill, R.N. Zare*, B.R. Smith* (2020). 12(4) 2752-2763. *Corresponding author

2019

Quantitative Drug Release Monitoring in Tumors of Living Subjects by Magnetic Particle Imaging Nanocomposite. Nano Letters. X. Zhu, J. Li, P. Peng, N. Hosseini-Nassab, B.R. Smith* (2019). 19(10) 6725-6733. *Corresponding author

2018

Extravasation of Brownian Spheroidal Nanoparticles through Vascular Pores. Biophysical Journal. P. Shah, T. Y. Lin, B.R. Smith*, E.S.G. Shaqfeh* (2018). 115(6), 1103-1115. *Co-corresponding authorship [Cover article]. HIGHLIGHTED IN: Stanford Engineering Magazine. Myers, A. New computer model designs a drug delivery strategy to fight cancer.

2015

Predictive Modeling of Drug Response in Non-Hodgkin’s Lymphoma. PLoS ONE. H. Frieboes*, B.R. Smith*, Z. Wang*, M. Kotsuma, K. Ito, A. Day, M. Loewenberg, B. Cahill, C. Flinders, S. Mumenthaler, P. Mallick, S.S. Gambhir, V Cristini. (2015). 10(6): e0129433. *Co-first authorship.

2014

Selective Uptake of Single-walled Carbon Nanotubes by Circulating Monocytes for Enhanced Tumour Delivery. Nature Nanotechnology. 9(6), 481-487. B.R. Smith^, E. Ghosn, H. Rallapalli, J. Prescher, L. Herzenberg, S.S. Gambhir^ (2014). 9(6), 481-487. ^Corresponding author. HIGHLIGHTED IN: Stephan, M. Carbon Nanotubes Are Picky Hitchhikers (2014).
Researchers elucidate the uptake mechanism of single-walled carbon nanotubes (2014). NANOMEDICINE. Science Translational Medicine. 6 (234) (Editor’s Choice) | Coaker, H. Vol: 9, Issue: 8. p. 1126. | Feature. Ten years in images. Nature Nanotechnology. 2016. 11, 836-840. | Blogs and other New Articles

2013

High-resolution, serial intravital microscopic imaging of nanoparticle delivery and targeting in a small animal tumor model. Nano Today [#2 ranked journal in Nanotechnology], B.R. Smith^, C. Zavaleta, Z. Liu, R. Tong, J. Ramunas, H. Dai, S.S. Gambhir^ (2013). 8(2) 126-137. ^Corresponding author.

An Integrated Computational/Experimental Model of Lymphoma Growth. PLoS Computational Biology. H. Frieboes, B.R. Smith, Y-L Chuang, K. Ito, A.M. Roettgers, S.S. Gambhir, V. Cristini (2013). 9(3): e1003008.

2012

Unexpected dissemination patterns in lymphoma progression revealed by serial imaging within a murine lymph node. Cancer Research. K. Ito*, B.R. Smith*, N. Parashurama, J-K, Yoon, S.Y. Song, C. Miething, P. Mallick, S. Lowe, S.S. Gambhir (2012).72, 6111-6118. *Co-first authorship.

Remodeling of Endogenous Mammary Epithelium by Breast Cancer Stem Cells. Stem Cells. N. Parashurama, N. Lobo, K. Ito, A. Mosely, F. Habte, B.R. Smith, J. Lam, I. Weissman, M.F. Clarke, S.S. Gambhir (2012). 30(10), 2114-2127. [Cover article].

Non-destructive, serial in vivo imaging of a tissue-flap using a tissue adhesion barrier: applications for IVM imaging in the mammary fat pad and lymph node. M. Kotsuma*, N. Parashurama*, B.R. Smith, K. Ito, S.S. Gambhir (2012). 1(1), 1-8. IntraVital. [Cover article].

Fluorescent Magnetic Nanoparticles for Magnetically Enhanced Cancer Imaging and Targeting in Living Subjects. ACS Nano. A. Fu, R.J. Wilson, B.R. Smith, J. Wright, C. Earhart, B. Bales, S. Guccione, S.X. Wang, S.S. Gambhir (2012). 6(8), 6862-6869.

Shape Matters: Intravital Microscopy Reveals Surprising Geometrical Dependence for Nanoparticles in Tumor Models of Extravasation. Nano Letters. B.R. Smith, P. Kempen, D. Bouley, A. Xu, Z. Liu, N. Melosh, H. Dai, R. Sinclair, S.S. Gambhir (2012). 12(7), 3369-77.

2011

Correlative Microscopy of Tumor Vasculature. Microscopy and Microanalysis. P. Kempen, B.R. Smith, M. Kircher, S.S. Gambhir, R. Sinclair (2011). 17 (Supp S2), 360-361.

2010

Dynamic Visualization of RGD-quantum dot Binding to Tumor Neovasculature and Extravasation in Multiple Living Mouse Models using Intravital Microscopy. B.R. Smith, Z. Cheng, A. De, J. Rosenberg, S.S. Gambhir (2010). Small. 6(20), 2222-2229. FEATURED ON: Frontispiece

A Comparison between Time Domain and Spectral Imaging Systems for Imaging Quantum Dots in Small Living Animals. Molecular Imaging and Biology. A. de la Zerda, M.L. Schipper, S. Keren, S. Bodapati, B.R. Smith, J.S.T. Ng, S.S. Gambhir (2010). 12(5), 500-508.

Assessing delivery and quantifying efficacy of small interfering ribonucleic acid therapeutics in the skin using a dual-axis confocal microscope. Journal of Biomedical Optics Letters. H. Ra, E. Gonzalez, B.R. Smith, S.S. Gambhir, G.S. Kino, O. Solgaard, R.L. Kaspar, C. Contag (2010). 15(3): 036027.

2009

Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy. Proceedings of the National Academy of Sciences. C. Zavaleta, B.R. Smith, I. Walton, W. Doering, G. Davis, B. Shojaei, M.J. Natan, S.S. Gambhir (2009). 106 (32), 13511-13516.

Functional and Transcriptional Characterization of Human Embryonic Stem-Cell-Derived Endothelial Cells for Treatment of Myocardial Infarction. PLoS ONE. Z. Li, K.D. Wilson, B.R. Smith, D. Kraft, F. Jia, X. Xie, M. Huang, G. Hoyt, P. Chu, R.C. Robbins, I.L. Weissman, S.S. Gambhir, J.C. Wu (2009). 4(12), 1-13.

Real-time visualization of RGD-quantum dot binding in tumor neovasculature using intravital microscopy in multiple living mouse models. Proceedings of SPIE. B.R. Smith, Z. Cheng, A. De, A.L. Koh, R. Sinclair, S.S. Gambhir (2009). Volume 7189, pp. 718915-718915-12.

Photoacoustic Molecular Imaging using Single Walled Carbon Nanotubes in Living Mice. Proceedings of SPIE. A. de la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S.Bodapati, R. Teed, Z. Liu, J. Levi, B.R. Smith, T-J, Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B.T. Khuri-Yakub, S.S. Gambhir (2009). Volume 7177, pp. 717725-717725-12.

2008

Endothelial Differentiation of Human Embryonic Stem Cell and Functional Blood Vessels Formation In Vivo. Blood. Z. Li, B.R. Smith, M. Huang, X. Xie, S.S. Gambhir, J.C. Wu (2008). 112(11), 5455.

Carbon Nanotubes as Photoacoustic Molecular Imaging Agents in Living Mice. Nature Nanotechnology. A. de la Zerda , C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B.R. Smith, T. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B.T. Khuri-Yakub, S.S. Gambhir (2008). 3, 557-562.

Real-time Intravital Imaging of RGD-Quantum Dot binding to Luminal Endothelium in Mouse Tumor Neovasculature. Nano Letters. B.R. Smith, Z. Cheng, A. De, A.L. Koh, R. Sinclair, S.S. Gambhir (2008). Sept; 8(9): 2599-2606. [Cover Article]

2007

Imaging of Atherosclerotic Plaques by Molecularly Targeted Nanoparticulates (USPIOs): Proof-of-Principle with MRI. Biomedical Microdevices. B.R. Smith, J. Heverhagen, M.V. Knopp, P. Schmalbrock, J. Shapiro, M. Shiomi, N.I. Moldovan, M. Ferrari, S.C. Lee (2007). 9:5, 719-727.

2005

The Molecular Analysis of Breast Cancer Utilizing Targeted Nanoparticulates (USPIOs): Proof-of-Principle with Ultrasound. Technology in Cancer and Research Treatment. J. Sakamoto, B.R. Smith, B. Xie, S. Rokhlin, S.C. Lee, M. Ferrari (2005). 4:6, 627-636.

Biologically-Targeted Super-paramagnetic Nanoparticulates to Atheromatous Plaque. Molecular Imaging. B.R. Smith, J. Heverhagen, M.V. Knopp, S.C. Lee (2005). 4:3, 312.

2002

Osmotic Pressures for Binary Solutions of Non-electrolytes. Biomedical Microdevices. V.T. Granik, B.R. Smith, S.C. Lee, M. Ferrari (2002). 4:4, 309-321.

Review Articles

2020

Nanotherapeutic shots through the heart. ACS Nano. Y. Kanthi, A. de la Zerda, B.R. Smith* (2020). 14(2) 1236-1242. *Corresponding author.

Optical Microscopy and Coherence Tomography of Cancer in Living Subjects. Trends in Cancer. P. Si, A. Honkala, A. de la Zerda*, B.R. Smith* (2020). 6(3) 205-222. *Corresponding author.

Nano-immunoimaging. Nanoscale Horizons. P. Wang, T. Kim, M. Harada, C. Contag, X. Huang, B.R. Smith* (2020). 5(4) 628-653. *Corresponding author.

2019

Non-spherical Micro- and Nanoparticles in Nanomedicine. Materials Horizons. X. Zhu, C. Vo, M. Taylor, B.R. Smith* (2019). 6: 1095-1121. *Corresponding author.

Nanoparticle Therapy for Vascular Diseases. Arteriosclerosis, Thrombosis, and Vascular Biology. A. Flores, J. Ye, K.U. Jarr, N.H. Nassab, B.R. Smith, N. Leeper (2019). 39: 635-646.

Magnetic Particle Imaging: Current development and clinical applications. Chinese Journal of Radiology. P. Peng, L. Li-Ling, B.R. Smith* (2019). 53(4) 426-430. *Corresponding author. (Chinese language)

2017

Cancer Immunotherapy Getting Brainy: Visualizing the Distinctive CNS Metastatic Niche to Illuminate Therapeutic Resistance. Drug Resistance Updates M. Owyong, N. Hosseini-Nassab, G. Efe, A. Honkala, R.J.E. Van den Bijgaart, V. Plaks*, B.R. Smith* (2017). . 33-35, 23-40. *Corresponding author.

HDL Nanoparticle Imaging in Atherosclerotic Vascular Disease. JACC BTS. N. Leeper, S-M Park, B.R. Smith* (2017). 2(1), 98-100. *Corresponding author.

Nanomaterials for In Vivo Imaging. Chemical Reviews. B.R. Smith*, S.S. Gambhir* (2017). 117(3) 901-986. *Co-corresponding authors.

2016

Carbon Nanotubes for Enhanced Biopharmaceutical Delivery. Reviews in Cell Biology and Molecular Medicine. Springer. H. Rallapalli, B.R. Smith* (2016). 2(1) 281-305. *Corresponding Author.

2009

Nanoparticulate iron oxide contrast agents for untargeted and targeted cardiovascular magnetic resonance imaging. Current Nanoscience. A.J. Nijdam, T.R. Nicholson, J.P. Shapiro, B.R. Smith, J.T. Heverhagen, P. Schmalbrock, M.V. Knopp, A. Kebbel, D. Wang, S.C. Lee (2009). 5(2), 88-102.

2004

Opportunities in Oncological Nanotechnology. Proceedings of the 1st International Symposium on Micro and Nano Technology. M. Sprintz, J. Sakamoto, B.R. Smith, M. Ferrari (2004). ISMNT, Honolulu, Hawaii. March, 2004.

A Biological Perspective of Particulate Nanoporous Silicon. Materials Technology. B.R. Smith, A.J. Nijdam, M.C. Cheng, X. Liu, S.C. Lee, M. Ferrari (2004). 19:1, 16-20.